Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
GT-222TOXICOLOGYCompulsory244
Level of Course Unit
First Cycle
Objectives of the Course
The aim of this course is to provide basic information on toxic dose, poisining, ,entrance ways of poisons to the body, toxiicodynamics, toxicokinetics, systemic toxicology and toxicological examination of chemical substances.
Name of Lecturer(s)
Öğr. Gör. Aşkın TEKİN
Learning Outcomes
1Students will have ability and skills in toxicity of solvents and heavy metals as well as industrial chemical and environmental pollutants
2Students will have ability and skills in toxicity of herbal, animal toxins and mycotoxins.
3Students will have ability and skills in the spectrum of toxic effects on target organs (blood, liver, kidney, nervous system, respiratory system, immune components and reproductive system).
4Students will have ability and skills in toxicological evaluation of chemicals and their mechanism of action.
5Students will have ability and skills in the definition and purpose of toxicology, absorption, distribution and excretion and biotransformation of toxicants with modifying factors. They will be able to carry out toxicological evaluation and assessment of Safety/Risk.
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
General Principles of Toxicology Dose, Toxic Dose, LD50, Absorption of Xenobiotics Distribution and Bioformation of Xenobiotics Factors Affecting Biotransformation, Toxicodynamics Chemical Carcinogenesis Mutagenesis Teratogenesis, Local Toxic Effects, Allergic Reactions Systemic Toxicology Evaluation of Toxicity Results and Risk Assessment Pharmacogenomics, Toxicogenomics Toxic Effects of Organic Solvents Toxic Effects of Animal and Plant Toxins Toxic Effects of Mycotoxins Metal Toxicity
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1General Principles of Toxicology
2Dose, Toxic Dose, LD50, Absorption of Xenobiotics
3Distribution and Bioformation of Xenobiotics
4Factors Affecting Biotransformation, Toxicodynamics
5Chemical Carcinogenesis
6Mutagenesis
7Teratogenesis, Local Toxic Effects, Allergic Reactions
8Midterm exam
9Systemic Toxicology
10Evaluation of Toxicity Results and Risk Assessment
11Pharmacogenomics, Toxicogenomics
12Toxic Effects of Organic Solvents
13Toxic Effects of Animal and Plant Toxins
14Toxic Effects of Mycotoxins
15Metal Toxicity
16Final exam
Recommended or Required Reading
Ellenhorn M.J., Ellenhorn's Medical Toxicology, Second Edition, Williams & Wilkins, London, 1997. Klaassen C.D., Watkins III J.B., Casarett & Doull's Essentials of Toxicology, The McGraw-Hill Companies, USA, 2003. Mann R.D., Andrews E.B., Pharmacogenetics and The Genetic Basis of Adverse Drug Reactions, John Wiley & Sons Ltd., 2007
Planned Learning Activities and Teaching Methods
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Examination1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Language of Instruction
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination11010
Final Examination11010
Attending Lectures14342
Team/Group Work11010
Self Study14114
Individual Study for Mid term Examination7214
Individual Study for Final Examination7214
TOTAL WORKLOAD (hours)114
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
LO1        
LO2        
LO3        
LO4        
LO5        
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Giresun University, Giresun / TURKEY • Tel  (pbx): +90 454 310 10 00 • e-mail: halklailiskiler@giresun.edu.tr